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Open Access Original Article Issue
Characteristic metabolic and microbial profiles in acute ischemic stroke patients with phlegm-heat pattern
Journal of Traditional Chinese Medical Sciences 2023, 10(3): 247-256
Published: 10 June 2023
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Objective

To explore the characteristics of plasma metabolites, feces gut microbiota and the crosstalk between gut microbiota and host metabolism in patients with acute ischemic stroke and phlegm-heat pattern (AIS-PHP).

Methods

The metabolic and microbiome profiles of 20 AIS-PHP patients and 20 healthy controls (HCs) were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and 16s rDNA sequencing, respectively. The covariation between LC-MS/MS-based metabolite data and 16s rDNA sequence data was presented.

Results

Distinct alterations in the plasma metabolic phenotype of AIS-PHP patients were found, in which 16 metabolites differed significantly between the AIS-PHP patients and the HCs. These metabolites represented 17 different metabolic pathways, including amino acid metabolism, lipid metabolism, and nucleotide metabolism. Additionally, significant alterations of gut microbiota composition and taxon were revealed at the phylum level between the AIS-PHP patients and the HCs. In AIS-PHP, Bacteroidetes, Firmicutes, and Proteobacteria dominated. Moreover, some microbes that differed between the 2 groups manifested a sole association with certain metabolites, such as the connection between Bacteroides and inosine and between Lachnospiraceae_unclassified and hypoxanthine.

Conclusion

The present study preliminarily investigated the metabolomic and gut microbiome characteristics of AIS-PHP patient indicators. The link between metabolic and microbial dysbiosis in AIS-PHP sheds new light on the function of gut microbiota and associated metabolomics in the pathogenesis of the disease.

Open Access Letter to the Editor Issue
Tiger face: characteristic manifestations of Meige syndrome
Brain Science Advances 2021, 7(4): 263-265
Published: 10 January 2022
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Meige syndrome is a neurological disorder discovered by Henry Meige, a French neurologist. The initial clinical manifestations are blepharospasm in both eyes and the characteristic facial appearance of tiger face lines. The patient displays an abnormal facial expression. Trauma, psychological, endocrine, and pharmacological factors may play a role in secondary Meige syndrome. Here we describe these clinical signs with pictures.

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