The mortality rate in the intensive care unit (ICU) is a key metric of hospital clinical quality. To enhance hospital performance, many methods have been proposed for the stratification of patients’ different risk categories, such as severity scoring systems and machine learning models. However, these methods make capturing time sequence information difficult, posing challenges to the continuous assessment of a patient’s severity during their hospital stay. Therefore, we built a predictive model that can make predictions throughout the patient’s stay and obtain the patient’s risk of death in real time. Our proposed model performed much better than other machine learning methods, including logistic regression, random forest, and XGBoost, in a full set of performance evaluation processes. Thus, the proposed model can support physicians’ decisions by allowing them to pay more attention to high-risk patients and anticipate potential complications to reduce ICU mortality.