To accurately evaluate ecological risks trigged by groundwater exploitation, it must be clarified the relationship between vegetation and groundwater. Based on remote sensing data sets MOD13Q1, groundwater table depth (WTD) and total dissolved solids (TDS), the relationship between groundwater and natural vegetation was analyzed statistically in the main plain areas of Qaidam Basin. The results indicate that natural vegetation is groundwater-dependent in areas where WTD is less than 5.5 m and TDS is less than 7.5 g/L. Aquatic vegetation, hygrophytic vegetation and hygrophytic saline-alkali tolerant vegetation are mainly distributed in areas with WTD <1.1 m. Salt-tolerant and mesophytic vegetation mainly occur in areas with WTD of 1.4-3.5 m, while the xerophytic vegetation isprimarily present in areas where WTD ranges from 1.4 m to 5.5 m. Natural vegetation does not necessarily depend on groundwater in areas with WTD >5.5 m. For natural vegetation, the most suitable water TDS is less than 1.5 g/L, the moderately suitable TDS is 1.5-5.0 g/L, the basically suitable TDS is 5.0-7.5 g/L, and the unsuitable TDS is more than 7.5 g/L.