Chinese medicine enema is an effective guiding method to treat diabetic kidney disease, a common chronic complication of diabetes, by regulating the function of the intestines to increase clearing and lower turbidity. We reviewed the treatment of diabetic kidney disease (DKD) with traditional Chinese medicine enemas and found that commonly used traditional Chinese medicines included Rhei Radix Et Rhizoma (Rheum palmatum L.), Ostrea concha (Ostrea gigas Thunberg), Taraxaci Herba (Taraxacum mongolicum Hand. -Mazz.), Astmgali Radix (Astragalus membranaceus Bge. var.mongholicus(Bge.) Hsiao), Salviae Miltiorrhizae Radix Et Rhizoma (Salvia miltiorrhiza Bge.), and Aconiti Lateralis Radix Praeparata (Aconitum carmichaelii Debx). The mechanism of the adjuvant therapeutic effect on DKD may relate to regulating intestinal flora, inhibiting inflammation and oxidative stress and protecting against kidney injury.