This paper presents a multi-scale and multi-chemo–physics platform to evaluate the lifecycle of structural concrete under environmental and mechanical impacts. Following the scheme from nanometer scale of cement hydrated with water molecule to meter scale of reinforced concrete (RC) members, the platform covers characteristic upscaling based on causality and behavioral response toward both environmental and mechanical impacts. During the process, multi-chemo–physics is incorporated to tackle the local equilibrium and global movement, where the associating impact is also considered with mesoscale cracks. With this platform, long-term structural performances are captured while the coupled durability issue is also investigated.