As an important part of water resources of the five countries of Central Asia, groundwater resources give critical supports to the regional economic development. Accompanied by rapid economic development, the demand of groundwater is increasing. As a result, the governments are paying more attention to groundwater resource development and utilization. However, there are noticeable issues and contradictions in water resource exploration in these countries. To be more specific, these countries lack the studies in development potential and conception planning, thus influencing the sustainable groundwater development. This paper mainly discusses groundwater development problems in the five countries of Central Asia, and briefly introduces volumes and distribution of transboundary groundwater. In addition, it analyzes the current exploitation status of groundwater and studies the potential in utilizing the resource. Most importantly, it proposes creative ways to address groundwater development issues: To make best of the resource, international cooperation is required.