In this paper, Tin (Ⅳ) oxide nanoparticles/graphene (SnO₂/GR) nanocomposites were prepared via vacuum thermo treatment of Tin (0) and graphene oxide (GO). A redox reaction would occur readily in this process, in which the novel oxygen donor: GO could act as the oxidizing agent to oxidize Tin (0) to Tin (Ⅳ), meanwhile, the graphene precursor: GO would be simultaneously reduced to graphene by Tin (0) readily. The resulted composites were characterized by Fourier transform infrared spectrometry, scanning electron microscopy, and X-ray diffraction spectroscopy ect.. The novel SnO₂/GR nanocomposites could combine both advantages of inorganic metal nanoparticles and graphene for near infrared spectroscopy (NIR) light absorption to generate heat, which fosters SnO₂/GR a special candidate for photothermal ablation therapy (PTA) with NIR. Further investigations show that the SnO₂/GR nanocomposites with NIR features could provide viable option for enhancing the thermal deposition and specificity of hyperthermia treatments for elimination of human prostate cancer (PC3).