Since cancer has been the biggest threat to our human beings’ health, more and more new patents of medical treatments for cancer detection have been used to make us out of suffering from cancer. Currently, most of patients check out their cancer cell at the late stage when cure is difficult, so early detection of cancer has been demonstrated to significantly important for improving clinical outcomes. But the current clinical methods available for such assessments are slow, expensive and inaccurate. There is a new development of nanosensor technology which makes it possible to detect the tumor earlier. The present paper summarizes recent new discoveries of nanosenor for tumor biomarker detection which allow for low-cost, minimally invasive approach with high sensitivity and specificity by detecting tumor biomarkers from the exhaled breath, proteomic, and molecule etc.