Over the past few years, supramolecular self-assembly chemistry has emerged as a new exciting field in which theoretical and experimental studies of structure and function of supramolecules have become a focus, and the importance of DNA, RNA, and peptides as important components to the fundamental development in life science has become a new interdisciplinary frontier in life science and other science. How to explain the origin of life phenomena has also become a hotspot. Here author expresses his some opinions to understand the self-assembly phenomena of nature from western philosophy view, explores the application prospects, and discusses the concepts, issues, approaches, and challenges, with the aim of stimulating a broader interest in developing supramolecular chemistry.