Myanmar is located in Southeast Asia within the Mekong River Basin. The estimated annual surface and groundwater potentials are 1081 km³ and 494 km³, respectively. Based on geological conditions, 11 different types of aquifers have been classified in Myanmar. The recent alluvial formation, Irrawaddy formation, Upper Pegu Group and Plateau limestone formation are the major water-bearing geologic formations of the country. In Myanmar, 89% of the groundwater is used for agriculture, approximately 8% is used for domestic consumption, and 3% is used for industrial purposes. Climate change projections for Myanmar from 2001 to 2100 predict general increases in temperature, clear-sky days, rainfall variability and flooding risks and a greater occurrence and intensity of extreme weather events across the country. Additional technology and investments are required to achieve groundwater resource security in response to climate changes. In addition, methods of ensuring the sustainability of groundwater resources must be implemented via collaborations with other countries and international sources.