Based on the mapping program of the map series of karst geology in China and Southeast Asia, the paper summarizes the application of remote sensing technique and the process of acquiring information from remote sensing images. Generally, remote sensing technique serves as an effective method to recognize information about karst topography, rocky desertification and karst collapse. Interpretation of remote sensing images, in combination with field verification and cartographic generalization, provides basic data for updating the program database and compiling synthetic maps. In interpreting remote sensing images, automatic extraction can make it more efficient and visual interpretation can improve its accuracy.