Omicron, the new mutant coronavirus, has spread rapidly globally, attracting close attention from different stakeholders worldwide. The complex and constantly changing epidemic situation has had a new impact on the world. Therefore, this paper focuses on the characteristics of the rapid spread of the COVID-19 variant strain. Generally, epidemic prevention experts conduct preliminary screening as part of the existing epidemic plan database according to the current local situation, after which they sort the alternatives deemed more suitable for the situation. Then the decision-makers identify the most divergent expert group, plan for consultation and adjustments, and finally obtain the plan with the smallest divergence. This article aims to integrate the experts’ opinions with the method of minimizing the differences, which can maximize the expert consensus and help organize the schemes that best meet the epidemic situation. The experts’ negotiation and iteration of the differences in the initial plan align with the current complex and dynamic epidemic situation and are of great significance to the rapid formulation of plans to achieve effective prevention and control.