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Open Access Corrigendum Issue
Corrigendum to ‘CRISPR/Cas9 system and its applications in nervous system diseases’ [Genes & Diseases 11 (2024) 675–686]
Genes & Diseases 2024, 11(6): 101392
Published: 19 August 2024
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Open Access Review Article Issue
CRISPR/Cas9 system and its applications in nervous system diseases
Genes & Diseases 2024, 11(2): 675-686
Published: 13 April 2023
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The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system is an acquired immune system of many bacteria and archaea, comprising CRISPR loci, Cas genes, and its associated proteins. This system can recognize exogenous DNA and utilize the Cas9 protein’s nuclease activity to break DNA double-strand and to achieve base insertion or deletion by subsequent DNA repair. In recent years, multiple laboratory and clinical studies have revealed the therapeutic role of the CRISPR/Cas9 system in neurological diseases. This article reviews the CRISPR/Cas9-mediated gene editing technology and its potential for clinical application against neurological diseases.

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