Porphyrinoid metal-organic frameworks (MOFs) with dual effective uranium uptake sites were synthesized through combined in-situ and post-synthetic method. The MOF10@5 demonstrates the uptake amount of uranium reaches 1476 mg/g under visible-light irradiation. The PN-MOF10@5 with dual uranyl uptake sites yields the amount of extracting uranyl of 1590 mg/g under visible-light irradiation. The density functional theory (DFT) calculations reveal strong interaction between uranyl and dual uranyl effective active sites. These MOFs demonstrate a powerful synthesis strategy for uranium extraction materials with dual effective active sites.