In 2023, the Nobel Prize in Chemistry was awarded to Bawendi, Brus, and Ekimov, three scientists who have made great contributions to the discovery and synthesis of quantum dots (QDs), heralding a new era for these nanomaterials. The inception of QDs dates back more than 40 years, during which the theory of QDs has been continuously refined, the manufacturing techniques have significantly flourished, and the applications have largely expanded. Recently, QDs have become important optical devices, playing key roles in numerous fields such as display, energy, and biomedical applications. To celebrate the outstanding achievements of QDs over the years, we dedicate this paper to QDs. In the information field, QDs have been extensively utilized to design devices related to domains like transmission and storage, achieving many breakthroughs in performance. This paper proposes a comprehensive set of methodologies and paradigms for designing information systems using QDs. The proposed approach embodies two characteristics of QDs: 1) QDs play a central role in every aspect of the system and possess the capability to construct an all-quantum-dot (All-QD) information system. 2) QDs possess tunability and wavelength flexibility, which can significantly enhance the information density. Finally, we construct a prototype model of an All-QD information system and validate its feasibility through simulation. We believe that with the continued development of quantum dot (QD) technology, the realization of an All-QD information system is on the horizon.