Single-cell RNA sequencing (scRNA-seq) technology measures the expression of thousands of genes at the cellular level. Analyzing single-cell transcriptome allows the identification of heterogeneous cell groups, cellular-level regulations, and the trajectory of cell development. An important aspect in the analyses of scRNA-seq data is the clustering of cells, which is hampered by issues, such as high dimensionality, cell type imbalance, redundancy, and dropout. Given cells of each type are functionally consistent, incorporating biological relations among genes may improve the clustering results. In light of this, we have developed a deep-embedded clustering method, G3DC. This method combines a graph regularization based on the pre-existing gene network and a feature selector based on the
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Open Access
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Big Data Mining and Analytics 2024, 7(3): 809-827
Published: 28 August 2024
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