A 2% scale, cruising version of a 450-seat class Blended-Wing-Body (BWB) transport was tested in the China Aerodynamic Research and Development Center’s FL-26 2.4-by-2.4-meter subsonic wind tunnel. The focus of the wind tunnel test was to investigate the aerodynamic performance of the latest BWB transport design, which would also aid in choosing a final engine arrangement in the three most potential engine integration layouts. The wind tunnel model can be tested with and without the nacelle and has three sets of different nacelle/tail integration positions. Computational Fluid Dynamics (CFD) simulations were performed in engine-aircraft integration design to find appropriate nacelle installing parameters of each layout. The comparison of CFD with experimental results shows good agreement. Wind tunnel measurements indicate that the tail-mounted engine layout produces the minimum drag penalty, while the fuselage-mounted engine layout increases drag the most. Experimental pressure measurement illustrates the effect of nacelle integration on the wing-body surface pressure distribution. This experimental and numerical research provides a reference for future BWB Propulsion-Airframe Integration (PAI) design.