Lubricin in synovial fluid is the primary boundary lubricant for articular cartilage. Its excellent boundary lubricating capability comes from unique bottlebrush structure. In this study, a biomimetic polymer containing 2-Hydroxyethyl acrylate and 2-methacryloyloxyethyl phosphorylcholine (MPC) was synthesized. This polymer is structurally similar to the lubricin and achieves a water-trapping capacity similar to lubricin through the design of pMPC moiety. Atomic Force Microscope (AFM) imaging indicates that changes in molecular chain length and concentration lead to different polymer self-assembled structures. Lateral force between AFM probe and silicon surface covered by the polymer demostrate that self-assembled structure of polymer molecules on the surface affects its boundary lubrication ability. When polymers are adsorbed onto the surface of articular cartilage to replace the natural lubricin, the system exhibits extremely low friction (∼0.028) under boundary film-liquid mixed lubrication conditions, which is close to the coefficient of friction (∼0.024) of natural lubricin under the same conditions. The study of this biomimetic polymer provides a strategy for lubricating damage cartilage during the initial stages of osteoarthritis development.