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Biochemical reactions in vivo occur at the temperature usually lower than that in vitro, however the underlying mechanism still remains a challenge. Inspired by our recent studies of adenosine triphosphate (ATP) releasing photons to resonantly drive DNA replication in a quantum way, we propose a quantized chemical reaction driven by multiple mid-infrared (MIR) photons. The space confinement effect of enzymes on a reactant molecule increases the lifetime of excitation state of its bond vibration, providing a chance for the bond to resonantly absorb multiple photons. Although the energy of each MIR photon is significantly lower than that of chemical bond, the resonant absorption of multiple photons can break the appointed bond of confined molecules. Different from the traditional thermochemistry and photochemistry, the quantized chemical reactions could have a high energy efficiency and ultrahigh selectivity. In addition, we also suggest a quantum driving source for our quantum-confined superfluid reactions proposed previously. The quantized chemical reaction resonantly driven by multiple MIR photons holds great promise to develop novel approaches for the chemical engineering in future.
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