The aim of the present study was to investigate if high amplitude high frequency oscillations (haHFOs) could be a biomarker of posttraumatic epileptogenesis.

After an initial craniotomy of rats and inducement of traumatic brain injury (TBI) through a fluid percussion, recording microelectrodes were implanted bilaterally in different brain areas. Wideband brain electrical activity was recorded intermittently from Day 1 of TBI and continued till week 21. HaHFO analysis was performed during the first 4 weeks to investigate whether the occurrence of this brain activity predicted development of epilepsy or not.

Of the 21 rats which received the TBI, 9 became epileptic (E+) and 12 did not (E−). HaHFOs were observed in the prefrontal and perilesional cortices, hippocampus, and striatum in both E+ and E− group. In comparison to the rats in E−, the E+ group showed a significant increase in the rate of haHFO from weeks 1 to 4 after TBI.

The results indicate that an increase in the rate of haHFOs after TBI could be an electroencephalographic biomarker of posttraumatic epileptogenesis.

The aim of the present study was to check the potential interaction of two neurodevelopmental proteins, Disc1 and Gas7, in the adult mice brain.

Twenty-four male Swiss albino mice were used for the study. The mice were 12 weeks old in the beginning of the experiment. Immunohistochemistry and co-immunofluorescence were performed on the coronal sections of mice brain and immunoblotting and co-immunoprecipitation were done on the whole brain lysate.

Data from immunohistochemistry and co-immunofluorescence indicate the occurrence and co-localization of Disc1 and Gas7 proteins in soma and projections of the brain cells. Immunostaining was observed in cerebral cortex, hypothalamus, midbrain, pons, medulla oblongata and CA3 of hippocampus of the brain. The data from Immunoblotting and co-immunoprecipitation validates the presence and interaction of Disc1 and Gas7 protein in whole brain lysate.

Data indicates the potential interaction of Disc1 and Gas7 protein in adult brain. The study highlights the need for further research on Disc1-Gas7 protein interaction in brain development and neuro-disorders.