Non-idealistic pharmaceutical, pharmacokinetic and therapeutic-characteristic predominately combines to decrease the effectiveness of certain composites. For the vectoring of such compounds to target areas, and liposomes and nanoparticles carrier technology provides an interesting and intelligent approach to drug delivery. It provides drug delivery by conjugating the drug to a transporter particle-like, microscopes, liposomes, nanoparticles, et cetera. Due to their small size and other effective properties, microspheres are an important portion of a drug-particle delivery system. The release systems are very important and can compare with the fabrication methods, this when the drug delivery become inside the body. This review highlights different types of drug delivery and drug delivery methods this article also focuses on different types of microspheres such as radioactive float microspheres biological adhesive microspheres, polymeric microbes, microspheres, and magnetic microspheres.