As a commonly used bone implant, Ti6Al4V alloy is prone to wear in human environment due to its corrosion resistance and poor wear resistance, resulting in their aseptic loosening and even implantation failure. Here, inspired of mussel adhesion chemistry, a novel hydrogel coating based on hydroxyapatite-modified MXene (PVA/PAA/PDA/HA-MXene) using a sol-gel method involving cyclic freezing and thawing, as well as chemical self-assembly techniques, on the surface of titanium alloy. The corrosion resistance and biotribological behaviors of the hydrogel coating on cortical bone were studied in simulated body fluid (SBF). The results demonstrated that the HA-MXene-based hydrogel coating exhibited outstanding biotribological and anti-corrosion properties. The novel HA-MXene-based hydrogel coatings can validly reduce the wear rate of cortical bone by 88.0 %, due to the formed lubrication film on the surface of hydrogel and the sliding and rolling friction mechanisms. Moreover, the enhanced anticorrosion properties of hydrogel coatings, optimally when the quantityof MXene arrived to 0.05 wt.%, were attributed to the blocking effect of MXene-based hydrogel. This study provides an innovative idea of surface modification design for the application of titanium alloy implants in the field of orthopedics.